The final diagnosis of Atypical Fibroxanthoma is made by expert pathological examination of a good quality, deep biopsy sample. Diagnosis is not straightforward, and special stains are often required to distinguish the AFX from ‘undifferentiated pleomorphic sarcoma’ (UPS).
The tumour is low grade but does require surgical excision with wide margins to keep the rate of recurrence to a minimum.
Mohs surgery is an additional option.
Atypical Fibroxanthoma may be diagnosed late for these reasons:
- Older guys may not be looking after themselves by, for example, getting a regular skin check and keeping an eye on their skin.
- The appearance of AFX probably won’t shout out ‘skin cancer’ because the appearance is non specific.
- The condition is rare.
AFX is a significant skin cancer in that treatment is more challenging than SCC or BCC.
Metastases (distance spread) occurs in 0.5% to 4% of cases.